Recombination and Error Thresholds in Finite Populations
نویسندگان
چکیده
This paper introduces the notions of quasi species and error threshold from molecular evolutionary biology The error threshold is a critical mutation rate beyond which the e ect of selection on the population changes drastically We reproduce using GAs and hence nite populations some interesting results obtained with an analytical model using in nite populations from the evo lutionary biology literature A reformulation of a previous analytical expression which explicitly indicates the extent of the reduction in the error threshold as we move from in nite to nite populations is derived Error thresholds are shown to be lower for nite populations Moreover as in the in nite case for low muta tion rates recombination can reduce the diversity of the population and enhance overall tness For high mutation rates however recombination can push the pop ulation over the error threshold and thereby cause a loss of genetic information These results may be relevant to optimizing the exploration exploitation balance in GAs Choices for critical GA parameters such as population size mutation and recombination rates should be reconsidered in the light of this new knowledge
منابع مشابه
Biological evolution through mutation, selection, and drift: An introductory review
5 Modelling mutational degeneration 23 5.1 Error thresholds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 5.1.1 The prototype model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 5.1.2 Methods of analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 5.1.3 Characterization of error thresholds . . . . . . . . . . . . . . . . . . . . ....
متن کاملThe Mathematics of Darwin’s Theory of Evolution: 1859 and 150 Years Later
A mathematical formulation of Darwin’s theory of evolutionary optimization through variation and selection is derived in terms of conventional ODEs that can be interpreted as chemical kinetics of evolution. Variation in form of mutation and recombination operates on genotypes being DNA or RNA sequences, whereas phenotypes, which are represented by organisms or molecular structures, are the targ...
متن کاملMaximum principle and mutation thresholds for four-letter sequence evolution
A four-state mutation–selection model for the evolution of populations of DNA-sequences is investigated with particular interest in the phenomenon of error thresholds. The mutation model considered is the Kimura 3ST mutation scheme, fitness functions, which determine the selection process, come from the permutation-invariant class. Error thresholds can be found for various fitness functions, th...
متن کاملRecombination can evolve in large finite populations given selection on sufficient loci.
It is well known that an allele causing increased recombination is expected to proliferate as a result of genetic drift in a finite population undergoing selection, without requiring other mechanisms. This is supported by recent simulations apparently demonstrating that, in small populations, drift is more important than epistasis in increasing recombination, with this effect disappearing in la...
متن کاملError Thresholds in Genetic Algorithms
The error threshold of replication is an important notion in the quasispecies evolution model; it is a critical mutation rate (error rate) beyond which structures obtained by an evolutionary process are destroyed more frequently than selection can reproduce them. With mutation rates above this critical value, an error catastrophe occurs and the genomic information is irretrievably lost. Therefo...
متن کامل